Element Web
Matrix & XMPPGlossy Matrix client for the web and desktop
Replaces Slack, Discord
Best Cross-Platform Matrix & XMPP for self-hosting
The 21 best Cross-Platform matrix & xmpp you can self-host, ranked by community traction.
Cinny
Matrix & XMPPSimple, elegant and secure Matrix client
Replaces Slack, Discord
Converse.js
Matrix & XMPPWeb-based XMPP/Jabber chat client
Replaces Slack
Openfire
Matrix & XMPPReal-time collaboration XMPP server written in Java
Replaces Slack, Microsoft Teams
FluffyChat
Matrix & XMPPCute, cross-platform Matrix messenger
Replaces WhatsApp, Telegram
Dino
Matrix & XMPPModern XMPP chat client for the desktop
Replaces Skype, Slack
Nheko
Matrix & XMPPDesktop Matrix client with native Qt interface
Replaces Slack, Discord
gomuks
Matrix & XMPPTerminal-based Matrix client written in Go
Replaces Slack, Discord
Profanity
Matrix & XMPPConsole-based XMPP client inspired by irssi
Replaces Slack
Syphon
Matrix & XMPPPrivacy-focused Matrix client built with Flutter
Replaces WhatsApp, Discord
Element X
Matrix & XMPPNext-generation fast Matrix client for mobile
Replaces WhatsApp, Signal
Fractal
Matrix & XMPPGNOME-native Matrix messaging client
Replaces Slack, Discord
Hydrogen
Matrix & XMPPWeb client for Matrix
CoyIM
Matrix & XMPPSecure desktop XMPP client with OTR encryption
Replaces Skype
Gajim
Matrix & XMPPFull-featured XMPP client with plugins
Replaces Skype, Slack
SchildiChat
Matrix & XMPPElement-based Matrix client with extra usability tweaks
Replaces Slack, WhatsApp
Ketesa
Matrix & XMPPAdmin UI for Matrix homeservers
Tigase XMPP Server
Matrix & XMPPHighly scalable XMPP/Jabber messaging server
Replaces Slack, WhatsApp
Commet
Matrix & XMPPCross-platform Matrix client built with Flutter
Replaces Discord, Slack
Prose
Matrix & XMPPXMPP client for team messaging
Replaces Discord, Facebook Messenger
Prosody
Matrix & XMPPModern XMPP communication server
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Every option here is open-source and self-hostable, tagged Cross-Platform within the matrix & xmpp category. Compare them on the individual app pages for setup difficulty and resource requirements.